The INA104 (PROACTIVE) study site close-out activity was completed in October 2023, and research documents from the site have been archived with the INDOARSIP vendor. Con-currently, the data management team is undertaking general cleaning of data that has been entered, following thorough quality assurance checks across the site.
The first post-close-out activity involves preparing the final study report. This report, based on an interim report, serves as an attachment for site closure notification to both the central ethics com-mission (FK-UI RSCM Ethics Committee) and local ethics committees. Notifications, along with the interim report, are slated for submission in December 2023. Additionally, if necessary, these will also be sent to the site Director/Education and Research Department.
The second post-close-out activity focuses on writing a scoping review. This review aims to comprehensively understand HIV research conducted in various fields and identify gaps in HIV research in Indonesia. It encompasses a thorough examination of HIV research reports and outcomes in Indonesia, from the early stages of the epidemic to the present. The Secretariat team, along with Re-search Assistants, are currently preparing the protocol scoping review. Simultaneously, they have begun searching and reviewing literature on HIV research in Indonesia using two journal databases:Pubmed and Garuda (Garba Rujukan Digital /Digital Referral Platform: https://garuda.kemdikbud.go.id/).
The third post-close-out activity is the preparation of manuscripts. The secretariat, study core team, and NIAID team, in collaboration with the PI and Co-PI from each site, are developing three main manuscripts. The first manuscript, focusing on baseline characteristics and predictors of mortality within one year (‘Baseline Characteristics and One-Year Mortality’), is in circulation among all teams and is targeted for publication in the Journal of the International AIDS Society.
The other two manuscripts are in the developmental phase. These include an initial analysis of mortality within three years (‘Early Analysis of Three-Years Mortality in People Living with HIV’) and a study on virological, immunological, disease, and clinical progression (‘Clinical, Immunological, and Virological Responses of HIV-infected People with AntiRetroviral Therapy in a Nationwide Indonesian Cohort’). Current efforts include determining the writing team and assigning specific responsibilities for the writing process. The composition of the writing teams for each manuscript is being decided based on the initial concept plans and the enthusiasm shown by the study sites.
Table 1. Ethic Committee List
