SEPSIS
SEPSIS (SEA-050) : An Observational Study of the Causes, Management, and Outcomes of Community-acquired Sepsis and Severe Sepsis in Southeast Asia
ClinicalTrials.gov: NCT02157259
Collaborator: SEAICRN, NIAID -HIH
Status: Completed
https://clinicaltrials.gov/study/NCT02157259
The SEPSIS observational study sought to identify the etiologies, management, and outcomes of community-acquired sepsis and severe sepsis in adults and children in Southeast Asia. The study was conducted by members of the Southeast Asia Infectious Disease & Clinical Research Network (SEAICRN) in Thailand, Vietnam, and Indonesia. In Indonesia, a total of 79 participants (65 adults, 14 children) were enrolled, between March 2015 and December 2015. All participants were hospitalized with a primary diagnosis of suspected or documented infection and had at least three sepsis diagnostic criteria. Rapid diagnostic tests, standard-of-care tests, and centralized research tests were performed using blood and other relevant specimen types collected at enrollment and, for a subset, during the 14- to 20-day convalescent period. Extensive data, including documented risk factors and antimicrobial resistance profiles, were systematically recorded throughout the 28-day study period.
Associated Publications:
- Causes and outcomes of sepsis in southeast Asia: a multinational multicentre cross-sectional study. Lancet Glob Health. 2017 Feb;5(2):e157-e167. doi: 10.1016/S2214-109X(17)30007-4. PMID: 28104185.
- Utility of SOFA score, management and outcomes of sepsis in Southeast Asia: a multinational multicenter prospective observational study. J Intensive Care. 2018 Feb 14;6:9. doi: 10.1186/s40560-018-0279-7. PMID: 29468069.
Associated Biorepository
| Identified Pathogen | Baseline | Day 14 – 20 | |||
| Whole blood | Plasma | Respiratory Swab in VTM | Serum | Serum | |
| Acinetobacter baumannii | 1 | N/A | 1 | N/A | N/A |
| Acinetobacter baumannii & Escherichia coli | N/A | 1 | N/A | 1 | N/A |
| Bocavirus | N/A | N/A | 1 | N/A | 1 |
|
Cytomegalovirus & Leptospira spp. |
1 | 1 | 1 | 1 | 1 |
| Coronavirus OC43 | 1 | 1 | 1 | 1 | N/A |
| Cytomegalovirus | 2 | 2 | 2 | 2 | 1 |
| Dengue virus | 5 | 3 | 2 | 3 | 2 |
| Dengue & Influenza B | 1 | 1 | 1 | 1 | 1 |
| Escherichia coli | 2 | 2 | N/A | 2 | N/A |
| Influenza B virus | 1 | N/A | 1 | 1 | 1 |
| Klebsiella pneumoniae | 1 | N/A | 1 | 1 | 1 |
| Leptospira spp. | 3 | 2 | N/A | 3 | 1 |
| Orientia tsutsugamushi | 1 | 1 | N/A | 1 | N/A |
| Parainfluenza virus | N/A | N/A | 1 | N/A | 1 |
| Pseudomonas aeruginosa | 1 | N/A | N/A | 1 | N/A |
| Rickettsia rickettsii | 1 | 1 | N/A | 1 | 1 |
|
Rickettsia rickettsii & Leptospira spp. |
1 | 1 | N/A | 1 | N/A |
| Rickettsia typhi | 4 | 1 | N/A | 4 | 3 |
| Rotavirus & Norovirus | 1 | 1 | N/A | 1 | 1 |
| Salmonella enterica typhi | 2 | 2 | N/A | 2 | 1 |
| Acinetobacter baumannii | 1 | N/A | 1 | N/A | N/A |
| Acinetobacter baumannii & Escherichia coli | N/A | 1 | N/A | 1 | N/A |
| Bocavirus | N/A | N/A | 1 | N/A | 1 |